MiNK Therapeutics Announces Clinical Data of Allogeneic iNKT Cells (agenT-797) in Solid Tumor Cancers at the AACR Annual Meeting
- Allogeneic iNKTs, agenT-797, administered alone or in combination with anti-PD-1 therapy, shows activity in patients with refractory solid tumor cancers.
- In a patient with metastatic gastric cancer who had no response to treatment with pembrolizumab and nivolumab/FOLFOX, agenT-797 induced a partial response with 42% tumor shrinkage, which continues beyond 9 months.
- AgenT-797 was administered without toxic lymphodepletion, persists for ~8 weeks, and appears to generate and drive immune cells into the tumor for destruction of cancer cells.
- HC Wainwright to host KOL webcast with
MiNK Therapeuticson Thursday, April 20th at 10:00am ETwith Investigators Dr. Benedito Carneiroand Dr. Yelena Janjigian.
“MiNK's groundbreaking research presented at AACR showcases a new era in cancer treatment with the potential to transform the lives of patients who have failed traditional therapies, including anti-PD-1 treatment," said Dr.
In a phase 1/2 trial, patients received a single infusion of agenT-797, alone or in combination with pembro or nivo, without lymphodepletion. Patients were heavily pretreated with a median of 4 prior lines of therapy and were unresponsive to prior anti-PD-1 therapy. The results showed that agenT-797 promoted durable responses, including a partial response and tumor reduction of >42% which was ongoing at 9 months in a patient with metastatic gastric cancer who had no response to prior treatment with pembro or nivo plus FOLFOX. Additionally, durable disease stabilization and biomarker responses were observed in NSCLC and testicular cancers refractory to anti-PD-1.
AgenT-797 was persistent and detectable in the periphery for > ~8 weeks and tolerable up to 1000x106 cells, with no neurotoxicity, dose-limiting toxicities, or severe cytokine release syndrome (> grade 3). Administration of agenT-797 induced a systemic and local anti-tumor response, driving immune cell infiltration into tumors and promoting immune cell activation.
HC Wainwright to host KOL webcast on
Registration is available at: https://my.ct.events/register.aspx?meid=4ea7d1f0-186b-41ae-833a-8f60df147d45&rpid=daae579e-ee18-4405-8ad9-a9fa6af17523
Invariant natural killer T (iNKT) cell therapies are a unique innate cell type that serve as master regulators of immune response, combining killing power of NK cells and the memory of T-cells. iNKTs can elicit a range of immune responses depending on the disease context, whether created by virus, bacteria, or cancer. AgenT-797 is an allogeneic unmodified iNKT cell product, designed for scalable “off-the-shelf” use. MiNK has established and launched house manufacturing and product release capacity to supply more than 5000 doses per year through an FDA-approved scalable, fully closed, and automatic iNKT manufacturing process.
The poster is available on the Publications page of MiNK Therapeutic’s Website.
Title: Phase 1 clinical update of allogeneic invariant natural killer T cells (iNKTs), agenT-797, alone or in combination with pembrolizumab or nivolumab in patients with advanced solid tumors
Presenting Author: Dr. Benedito Carneiro
Abstract Number: CT275
Session Title: Phase I Clinical Trials 2
Session Date and Time:
Forward Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding the therapeutic and curative potential of agenT-797 and iNKT cells the mechanism of action, potency and safety, interim or top-line data, including statements regarding clinical data of agenT-797 alone and in combination with anti-PD-1, the anticipated benefits of agenT-797 and clinical development plans and timelines. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These forward-looking statements are subject to risks and uncertainties, including the factors described under the Risk Factors section of the most recent Form 10-K, Form 10-Q and the S-1 Registration Statement filed with the SEC. MiNK cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and MiNK undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.
Source: MiNK Therapeutics